This is an interated integral. I choose to integrate with \(x\) in the inside and \(y\) on the outside. Then the integral proceeds as two consecutive single-variable integrals. The integral is well defined, since none of the line that solve either of the three factors in the denominator pass through the interval in question. In the first step for \(x\text{,}\) I need to use partial fractions to break up the integrand.
\begin{align*}
\amp \int_2^4 \int_{-1}^1 \frac{1}{(x+y)(x+2y)(x+3y)} dx dy\\
\amp = \int_2^4 \int_{-1}^1 \frac{\frac{1}{2y^2}}{x+y} +
\frac{\frac{-1}{y^2}}{x + 2y} + \frac{\frac{1}{2y^2}}{x +
3y} dx dy\\
\amp = \int_2^4 \frac{1}{2y^2} \ln |x+y| - \frac{-}{y^2}
\ln |x+2y| + \frac{1}{2y^2} \ln |x+3y| \bigg|_{-1}{1} dy\\
\amp = \int_2^4 \frac{1}{2y^2} (\ln |1+y| - \ln |-1+y|) -
\frac{1}{y^2} (\ln |1+2y| - \ln |-1+2y|) \\
\amp + \frac{1}{2y^2}
(\ln |1+3y| - \ln |-1+3y|) dy
\end{align*}
I can split this up into six different integrals, all of which are annoying to do. Integration by parts in each integral can remove the logarithmic part, leaving a rational function. Partial fractions can then deal with the rational functions. I skipped the details here, giving just the six integrals and their values calculated by a computer algebra system. Turns out it was a reasonable thing that I did so, since the numbers get quite miserable.
\begin{align*}
\amp = \int_2^4 \frac{1}{2y^2} \ln |1+y|
- \int_2^4 \frac{1}{2y^2} \ln |-1+y|
- \int_2^4 \frac{1}{y^2} \ln |1+2y| \\
\amp + \int_2^4 \frac{1}{y^2} \ln |-1+2y|
+ \int_2^4 \frac{1}{2y^2} \ln |1+3y|
- \int_2^4 \frac{1}{2y^2} \ln |-1+3y| \\
\amp = \frac{1}{8} \ln \frac{256}{3125}
- \frac{1}{4} \ln \frac{4}{27}
+ \frac{1}{8} \ln \frac{27}{256}
+ \frac{\ln 2}{2}
+ \ln \frac{100}{81} \\
\amp + \frac{1}{2} \ln \frac{5}{3}
+ \frac{1}{2} \ln 3
+ \ln \frac{49}{36}
- \frac{1}{4} \ln 7
+ \frac{1}{8} \ln \frac{1677216}{13^{13}}
- \frac{1}{4} \ln \frac{64}{823543}
\end{align*}